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Standardized soursop leaf extract
product description
Our soursop leaf extract powder is derived from the dried leaves of Annona muricata (commonly known as Soursop, Graviola, or Guanábana), a tropical evergreen tree native to the Caribbean, Central America, and Southeast Asia. We source raw leaves from contract farms in Vietnam and Indonesia, where warm tropical climates and mineral-rich volcanic soil produce leaves with consistently high concentrations of annonaceous acetogenins, alkaloids, and flavonoids.
Each batch of raw leaves is harvested at peak maturity (6–8 months after leaf flush), shade-dried within 24 hours to preserve thermolabile phytochemicals, and visually inspected for foreign matter before entering our extraction facility in Shaanxi, China.
Available Specifications
We offer two standard extraction ratios, with custom ratios available upon request:
4:1-20:1 Extract —Ideal for general-use herbal supplements, functional beverages, and herbal tea blends where a balanced phytochemical profile is preferred.
2.5% flavonoid—Recommended for high-potency capsule formulations, liquid drops, and concentrated nutraceutical products where dosage precision and smaller pill size are critical.
Both ratios are produced via low-temperature water-ethanol dual extraction (ethanol concentration ≤ 60%, extraction temperature ≤ 55°C), which maximizes recovery of both polar (flavonoids, alkaloids) and non-polar (acetogenins) bioactive compounds while avoiding thermal degradation.
Why Standardized Leaf Extract?
Unstandardized leaf powders vary naturally with harvest season, origin, and drying method. Our extract is standardized to ≥2.5% flavonoid (HPLC) with a defined content, so formulators can dose on a consistent marker basis from batch to batch. The fine powder blends cleanly into capsules, tablets, tea blends, and stick pouches, and it is frequently paired with other antioxidant botanicals in immune and wellness formulas. Clean-label credentials — Non-GMO, vegan-friendly, organic option — make it a strong fit for premium brands.
Manufacturing & Quality Control
Raw Material Traceability — Leaves are sourced from qualified plantations and screened for pesticides, heavy metals, and microbial load before release.
Controlled Extraction — Water/ethanol extraction under controlled temperature preserves acetogenin and flavonoid integrity; concentration ratio is set per order.
Batch-by-Batch Testing — HPLC markers, flavonoids, moisture, ash, particle size, heavy metals, and microbiology are verified on every lot.
Sealed Warehousing — Cool, dry, light-protected storage maintains marker stability across the 24-month shelf life.
product benefits
1 Potent Antioxidant Activity
Soursop leaf extract contains a rich profile of phenolic compounds, flavonoids, and acetogenins that function as free-radical scavengers. In vitro studies using DPPH radical scavenging assays have reported IC₅₀ values in the range of 140–150 μg/mL for ethanol extracts of A. muricata leaves, indicating moderate-to-strong antioxidant capacity. The extract has also been shown to upregulate endogenous antioxidant enzymes — including superoxide dismutase (SOD) and catalase — while downregulating mitochondrial NADPH oxidase complex I activity, reducing reactive oxygen species (ROS) generation at the cellular level.
For supplement formulators, this dual mechanism (direct scavenging + endogenous enzyme modulation) makes soursop leaf extract a valuable addition to antioxidant blends, cellular defense formulas, and anti-aging nutraceuticals.
2 Anti-Inflammatory Support
Preclinical research demonstrates that A. muricata leaf extract suppresses pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and inhibits key inflammatory enzymes including cyclooxygenase (COX) and lipoxygenase (LOX). In rat models of acute and chronic inflammation, the extract exhibited activity comparable to indomethacin, a standard NSAID, during both neurogenic and inflammatory phases. A 2024 study in Frontiers in Nutrition further confirmed that soursop leaf extract attenuated oxidative stress and inflammatory cytokine levels in L-NAME-induced hypertensive rats.
These properties support applications in joint health formulas, sports recovery supplements, and inflammation-modulating herbal blends.
3 Immune System Modulation
Traditional use of soursop leaf tea for immune support is backed by emerging research on the extract's immunomodulatory and antimicrobial properties. In vitro studies have documented antiviral and antibacterial activity, with ethanolic extracts showing protective effects against oxidative hemolysis in human erythrocytes (51.2% inhibition at tested concentrations). The alkaloid and acetogenin fractions are believed to contribute to these effects.
For B2B clients, this positions soursop leaf extract as a functional ingredient in immune-support capsules, seasonal wellness blends, and herbal tincture formulations.
4 Metabolic & Cardiovascular Support
Animal studies have explored soursop leaf extract's effects on metabolic parameters. Research published in Nutrients (PMC6682994) demonstrated that A. muricata extract prevented high-fat diet-induced metabolic disorders in C57BL/6 mice, improving lipid profiles and reducing atherogenic risk markers. The 2024 Frontiers in Nutrition study additionally reported blood pressure-lowering and lipid-improving effects in hypertensive rat models, attributed to the extract's antioxidant and anti-inflammatory mechanisms.
These findings support inclusion in cardiovascular support formulas, metabolic health blends, and cholesterol-management supplements.
5 Gastrointestinal Protection
A study published in the World Journal of Gastroenterology (PMC4218895) demonstrated that A. muricata leaves exerted gastroprotective activity against ethanol-induced gastric injury in rats, mediated through Hsp70 upregulation and Bax downregulation — pathways involved in gastric mucosal protection and apoptosis regulation. The extract also suppressed pro-inflammatory cytokines in gastric tissue.
This makes soursop leaf extract suitable for digestive health formulas, gastric support blends, and gut-barrier supplements.
6 Neuroprotective Potential (Emerging Research)
A 2024 study in the Iranian Journal of Basic Medical Sciences (PMC11790190) found that A. muricata leaf extract and fractions protected the hippocampus and prefrontal cortex in scopolamine-induced memory impairment models in mice, modulating acetylcholinesterase activity and antioxidant enzyme levels. While these are preclinical findings and human data remains limited, they suggest potential for cognitive support and nootropic formulations — an area of growing consumer demand.
Important Note: While preclinical research is promising, human clinical trials remain limited. As a B2B raw material supplier, we provide this information for formulation reference only. End-product claims must comply with the regulatory requirements of your target market (FDA DSHEA in the US, EFSA in the EU, etc.).
product Applications
1 Dietary Supplements & Nutraceuticals
The largest application segment for soursop leaf extract powder. Common finished forms include:
Capsules & Tablets — 250–500 mg per serving, typically 10:1 or 20:1 extract. Suitable for immune support, antioxidant, and cellular defense formulas.
Liquid Drops & Tinctures — Highly soluble in ethanol-water systems. Popular in "bitters" and wellness drops, often blended with sea moss, moringa, turmeric, black seed oil, and ashwagandha.
Powder Blends & Stick Packs — Easily incorporated into green superfood blends, detox powders, and herbal coffee alternatives.
Softgels — For oil-based delivery systems when combined with suitable carrier oils.
2 Functional Foods & Beverages
Herbal Tea Blends — Soursop leaf extract powder can be standardized and blended with other tropical botanicals for consistent potency in tea bags and loose-leaf blends.
Functional Beverages — Suitable for inclusion in wellness shots, herbal energy drinks, and ready-to-drink (RTD) functional beverages (note: partial water solubility may require emulsification or suspension systems).
Nutrition Bars & Snacks — Incorporated into protein bars, energy balls, and functional snack products targeting the natural wellness consumer.
3 Cosmetics & Personal Care
The antioxidant and anti-inflammatory properties of soursop leaf extract make it a candidate for:
Face Serums & Creams — Added to anti-aging and skin-brightening formulations for free-radical protection.
Body Lotions & Balms — Included in soothing topical products for irritated or inflamed skin.
Hair Care Products — Added to scalp treatments and hair serums for antioxidant support.
4 Animal Nutrition & Pet Supplements
Emerging application in pet wellness supplements, particularly for dogs and cats, in the form of chewable tablets and powder toppers for immune and joint support. Note: dosage and safety for veterinary use should be independently verified by a qualified animal nutritionist.
4.5 Traditional Herbal Medicine
It used as a component in polyherbal formulations by practitioners of Caribbean, Latin American, and Southeast Asian traditional medicine systems, often for immune, digestive, and general wellness support.
FAQ
Q: What is the minimum order quantity (MOQ)?
A: For standard 10:1 and 20:1 extracts in stock packaging, the MOQ is 25 kg. For custom extraction ratios, standardized marker compounds, or custom packaging, the MOQ is 100 kg.
Q: Can you provide a Certificate of Analysis (COA) before I order?
A: Yes. We provide a COA for every production batch with actual test results. For prospective clients, we can share a representative COA from a recent batch as a reference. Once you place an order, the specific batch COA will be included with your shipment documents. We can also arrange for pre-shipment sample approval — you test and approve the sample before we ship the full order.
Q: How do you ensure heavy metal compliance?
A: Heavy metal testing is a non-negotiable QC step for every batch. We use ICP-MS (Inductively Coupled Plasma Mass Spectrometry) to test for lead, arsenic, cadmium, mercury, and other elemental impurities. Our internal limits are stricter than most industry standards (e.g., Pb ≤ 2.0 mg/kg vs. the common ≤ 10 mg/kg). We also offer ICH Q3D elemental impurity testing for pharmaceutical-grade clients. All results are reported on the batch COA.
Q: What is the shelf life and how should the product be stored?
A: The shelf life is 24 months from the date of manufacture when stored in unopened, original packaging. Store in a cool, dry place (temperature ≤ 25°C, relative humidity ≤ 60%), away from direct sunlight, strong odors, and volatile compounds. Once opened, we recommend resealing tightly and using within 6 months. For long-term storage of bulk quantities, nitrogen flushing and cold storage (2–8°C) can extend stability.
Q: Is soursop leaf extract water soluble?
A: Soursop leaf extract powder is partially soluble in water. The water-soluble fraction (flavonoids, phenolic acids, alkaloids) dissolves readily, while the less polar compounds (acetogenins, essential oils) may cause slight cloudiness or sedimentation. For clear beverage applications, we recommend: (1) using a solubility-enhanced spray-dried extract with maltodextrin carrier, (2) incorporating an emulsifier or suspension system (gum arabic, xanthan gum, lecithin), or (3) formulating in an ethanol-water or glycerin base (tinctures, liquid drops).
Q: Can you customize the extract for my specific formulation?
A: Absolutely. We offer full customization including: extraction ratio (4:1 to 50:1), solvent system (water, ethanol, methanol-free), marker compound standardization (e.g., acetogenins ≥ 1%, total flavonoids ≥ 5%), particle size (micronization to D90 ≤ 30 μm), carrier systems (maltodextrin, gum arabic, inulin), and packaging. Our R&D team can collaborate with you on formulation feasibility and provide prototype samples for testing. Custom projects typically require 15–25 working days from PO to shipment.
Q: What are the shipping options and delivery times?
A: We offer multiple shipping terms:
Express courier (DHL/FedEx/UPS): 3–7 business days, ideal for samples and small orders (< 50 kg)
Air freight: 5–10 business days, suitable for orders 50–500 kg
Sea freight (LCL/FCL): 20–40 business days depending on destination, most cost-effective for bulk orders (> 500 kg)
DDP (Delivered Duty Paid): Available for select destinations — we handle customs clearance and delivery to your door
Standard lead time for stock items is 3–5 working days from payment confirmation.
KH Health is your trusted partner, dedicated to listening to customers, solving every problem, and providing quick responses. For any questions or assistance regarding, feel free to contact us at:
Email: sales@kh-health.com
WeChat: +86 13096987266
WhatsApp: +86 18792880979
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