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What is 98% natural berberine?
Berberine (bsae) is a naturally occurring isoquinoline alkaloid with a long history of medicinal use in traditional Chinese medicine and one of the most studied botanical actives in modern nutrition science. With a purity of ≥98% (HPLC) , our natural berberine powder is a bulk raw material widely used in dietary supplements, functional foods, pharmaceutical intermediates and animal nutrition.
Our natural berberine is extracted exclusively from botanically identified plant sources — the rhizomes of *Coptis chinensis* (Chinese goldthread), the bark of *Phellodendron amurense / chinense* (Amur cork tree) and the roots of *Berberis* species — collected from contracted GAP-managed cultivation bases. The alkaloid is obtained through aqueous/ethanolic extraction and purified by crystallization to ≥98% purity. We declare the botanical source on every batch and support full raw-material traceability from field to finished powder.
Third-party report
Before we ship we can also send some samples to another lab for testing.
You can choose a lab, like Eurofins, SGS, AIE or any other lab you prefer.
product benefits
Natural berberine 98% is the form used in the majority of published clinical research. It works through multiple mechanisms — most notably activation of AMPK, the body's "metabolic master switch" — and is associated with the following evidence-based benefits (statement-level, for formulators' reference):
Blood glucose & metabolic support
Blood glucose & metabolic support
Multiple randomized controlled trials show berberine (typically 500 mg, 2–3× daily) reduces fasting blood glucose and HbA1c in individuals with type 2 diabetes or prediabetes, with glycemic control comparable to metformin in a landmark comparative study. A 12-week placebo-controlled pilot trial (2023) confirmed significant improvements in glycemic markers in prediabetic subjects.
Lipid & cardiovascular risk-marker support
Clinical studies report reductions in total cholesterol, LDL-C and triglycerides; 2026 randomized placebo-controlled trials further demonstrated apolipoprotein B (apoB) reductions with berberine supplementation.
Gut health & intestinal support
Berberine has a long traditional record for digestive comfort and demonstrates antimicrobial and anti-inflammatory activity against common intestinal pathogens; extended follow-up of a clinical trial (NCT02226185) found reduced colorectal adenoma recurrence persisting up to 6 years after treatment.
Weight management support
By improving insulin sensitivity, glucose and lipid metabolism, berberine supports modest weight loss (~1–2 kg over 12 weeks in trials) and preferential reduction of visceral fat — a complement, not a substitute, to GLP-1 medications.
Antioxidant & anti-inflammatory activity
Preclinical and human studies associate berberine with reduced inflammatory markers and oxidative stress, supporting its role in metabolic syndrome, NAFLD and PCOS research programs.
All benefit statements are summaries of published scientific literature for formulation reference. Our bulk berberine powder is sold as a raw material for manufacturers; finished-product claims must comply with applicable regulations in the target market.
Why choose us
Free samples: 5 g evaluation sample with COA before your first order
Flexible MOQ: trial orders from 1 kg; volume pricing for 25 kg / 100 kg / MT
OEM / ODM & private label: capsules, tablets, sachets, custom blends, your brand, your formula or ours
Custom packaging & labeling: retail-ready or bulk export packing; label artwork support
Full documentation package: COA, MSDS, allergen statement, non-GMO & organic declarations, TDS, flow diagram
Regulatory support: USP/EP/CP compliance files, DMF assistance, Halal/Kosher certificates
Logistics: DHL/FedEx/UPS air express, sea freight; worldwide delivery with full export documentation
After-sales & technical support: dedicated account manager; formulation and dosage guidance from our technical team
case study
North American dietary supplement brand (private label)
A US-based brand sourcing 98% food-grade berberine for a 1,200 mg daily supplement line required Kosher/Halal certification, a 3rd-party-verified COA and batch-to-batch consistency. We supplied trial samples within 7 days, completed a supplier audit in 2 weeks, and delivered 10,0000 bottles at first with 100% on-time dispatch. Result: the brand shortened supplier qualification time by 30% and launched on schedule for its retail program.
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Q: Is your berberine natural or synthetic?
A:100% natural. Our berberine is extracted from Coptis chinensis rhizome, Phellodendron bark or Berberis root — never synthesized from petrochemical intermediates.
Q: What is the difference between berberine and berberine HCL?
A:Berberine HCL is the hydrochloride salt form of the berberine alkaloid — the same active compound, converted to a salt for easier handling in supplements.
Q: What purity grades do you supply?
A:Standard grades: 97%, 98% (HPLC) and USP/EP-grade.
Q: What is the MOQ? Do you offer free samples?
A:MOQ is 1 kg for trial orders; free evaluation sample available upon request with a valid business profile.
Q: Can it be used in animal feed and aquaculture?
A:Yes. Feed-grade berberine is used as a natural antibiotic-alternative additive for swine, poultry and livestock, and in aquaculture for gut health and disease prevention.
Q: What are the storage conditions, shelf life and packaging?
A:Store tightly sealed, in a cool, dry place, protected from light. Shelf life 24 months. Standard packaging: 1 kg foil bags / 25 kg fiber drums (double PE-lined), or custom pack per request.
Q: What is your lead time and payment terms?
A:In-stock items ship within 3 days; production orders in 7–15 days after deposit. Payment: T/T, L/C, PayPal, etc. — discuss with our sales team.
If you are looking for a reliable supplier, we provide high-purity coptis chinensis extract berberine for supplements, supplement brands, and beverage companies. Contact us for more details about specifications, certificates, and pricing.
Email: sales@kh-health.com
WeChat: +86 13096987266
WhatsApp: +86 18792880979
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