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Nattokinase enzyme powder
product description
Nattokinase powder is a fibrinolytic enzyme produced through the controlled fermentation of soybeans by Bacillus subtilis natto — the organism behind Japan's traditional natto. It supports healthy circulation and cardiovascular function by helping maintain normal fibrin levels.
KH Health manufactures nattokinase under strict fermentation and purification controls, standardizing activity at 20,000, 40,000 FU/g or custom levels from 10,000 to 100,000 FU/g. Plain and enteric-coated powders are available, and every batch is assayed for fibrinolytic activity before release.
Third-party testing report
We can provide reports from our in-house testing laboratory as well as third-party test reports from organizations such as Eurofins, SGS, and AIE.
Controlled Processing
Strain Control
Qualified Bacillus subtilis natto strains maintained under strict culture controls.
Controlled Fermentation
Precision fermentation on soybean substrate with monitored temperature, pH and time.
Harvest & Purification
Cell separation, filtration and multi-step purification concentrate the enzyme.
Drying & Blending
Freeze- or spray-drying protects activity, then blending standardizes FU/g with carriers.
Coating Option
Enteric coating provides acid resistance for intestinal release in sensitive formulas.
QC & Stability
Fibrinolytic activity assay per batch plus 24-month stability studies under varied conditions.
product benefits
1 Fibrinolytic Activity
Nattokinase is a serine protease that directly degrades fibrin (the structural protein of blood clots) and simultaneously activates the body's endogenous fibrinolytic cascade by converting plasminogen to plasmin and enhancing tissue plasminogen activator (t-PA) activity. Unlike many oral enzymes that are denatured in the stomach, nattokinase demonstrates **resistance to gastric pH (stable to pH 9) and temperatures up to 50°C**, allowing a meaningful fraction to survive gastrointestinal transit and exert systemic effects.
2 Blood Pressure Support
A randomized, double-blind, placebo-controlled trial in subjects with elevated blood pressure found that 8 weeks of oral nattokinase supplementation reduced systolic BP by 5.55 mmHg and diastolic BP by 2.84 mmHg (P < 0.05) versus placebo. A 2024 systematic review and meta-analysis of RCTs confirmed significant reductions in both systolic (MD = −3.45 mmHg) and diastolic (MD = −2.32 mmHg) blood pressure across pooled data.
3 Lipid & Atherosclerosis Management
Large-scale clinical research (1,062 participants) demonstrated that nattokinase supplementation significantly improved lipid profiles and reduced atherosclerotic plaque progression. Mechanistically, nattokinase activates hormone-sensitive lipase (HSL), inhibits HMG-CoA reductase, and enhances lipoprotein lipase (LPL) activity — three distinct pathways contributing to lipid-lowering and anti-atherosclerotic effects. Animal data suggest nattokinase may outperform simvastatin (20 mg/day) in reducing atherosclerotic plaque area in certain models, though human head-to-head data remain limited.
4 Circulation & Microvascular Flow
A double-blind, placebo-controlled crossover study showed that a single oral dose of nattokinase accelerated skin temperature recovery after cold-water immersion, indicating improved peripheral microcirculation. This finding supports applications in formulas targeting cold extremities, post-exercise recovery, and general circulatory comfort.
5 Cognitive & Vascular Health
Preliminary clinical research published in 2026 reported that nattokinase supplementation improved cerebral blood flow velocity in 71.4% of subjects with abnormal hemodynamics and reduced carotid plaque in 46.7% of participants. While larger confirmatory trials are needed, these data position nattokinase as a candidate ingredient for vascular cognitive support formulations.
Product Application
1 Dietary Supplements & Nutraceuticals
- Cardiovascular support capsules/tablets: The dominant application, typically dosed at 100–200 mg (2,000–4,000 FU) per serving. Often formulated with serrapeptase, bromelain, CoQ10, omega-3, or magnesium.
- Blood pressure management formulas: Positioned alongside hibiscus extract, olive leaf extract, and potassium.
- Circulation & "healthy legs" formulas: Combined with horse chestnut, butcher's broom, and gotu kola for venous insufficiency support.
- Cognitive / brain-health blends: Emerging category, paired with Ginkgo biloba, bacopa, and lion's mane for vascular cognitive support.
2 Functional Food & Beverages
- Functional beverages & ready-to-drink (RTD) shots: Water-soluble powder allows incorporation into wellness shots, electrolyte drinks, and "heart-healthy" beverage lines. Recommended dose: 2,000 FU per 30–60 mL serving.
- Stick packs & oral dissolvable films: Fast-dissolve formats for on-the-go cardiovascular support; the neutral taste minimizes need for strong flavor masking.
- Functional gummies & chews: Heat-sensitive — recommend adding post-cooling or using microencapsulated grade to preserve activity through gummy processing.
- Protein & meal-replacement powders: Blended into "cardio-conscious" protein powder SKUs; compatible with whey, plant protein, and collagen matrices.
3 Cosmeceuticals & Topical Care
- Anti-aging serums & creams: Nattokinase's fibrin-degrading and anti-inflammatory properties are being explored in topical formulations for improved microcirculation, reduced under-eye puffiness, and enhanced skin tone.
- Scalp & hair care: Improved scalp microcirculation is a mechanistic rationale for inclusion in hair-growth serums, often alongside caffeine, rosemary oil, and biotin.
4 Pet Nutrition & Veterinary Supplements
- Canine & feline cardiovascular support: Growing category in premium pet supplements, particularly for senior breeds predisposed to cardiac conditions. Typically dosed at 500–1,000 FU per 10 kg body weight, in chewable tablet or powder form.
- Equine performance supplements: Used in endurance and race-horse formulas for circulatory support and post-exercise recovery (regulatory compliance varies by jurisdiction — verify before formulation).
5 Industrial & Research Applications
- Diagnostic reagent component: Nattokinase's specific fibrinolytic activity makes it useful in research-grade fibrin degradation assays and clot lysis test kits.
- Biomedical research material: Supplied to universities and contract research organizations for in vitro and in vivo studies on thrombosis, atherosclerosis, and enzyme delivery systems.
brand case
OEM Project for a North American Dietary Supplement Brand: A well-known US health supplement brand sought a high-purity, odorless Nattokinase ingredient with FDA GRAS status. We supplied a customized 20,000 FU/g freeze-dried powder and collaborated on formulation stability testing. The final product launched successfully, resulting in a 30% increase in the repeat purchase rate.
European Functional Gummy Manufacturer: A European client needed to address the issue of Nattokinase inactivation during the high-temperature gummy cooking process. We provided a heat-resistant, microencapsulated Nattokinase ingredient that retained over 85% of its activity after processing, successfully enabling the client to launch an innovative cardiovascular-support gummy product.
FAQ
Q:What does FU/g mean?
A:FU (Fibrinolytic Units) measures nattokinase enzyme activity per gram. Higher FU/g means more concentrated fibrinolytic activity; we supply 20,000, 40,000 FU/g and custom levels.
Q:Why is enteric-coated nattokinase offered?
A:Enteric coating protects the enzyme from stomach acid so activity is released in the intestine, improving delivery for sensitive consumers and high-activity formulas.
Q:Is nattokinase suitable for vegetarians?
A:Yes — it is produced by microbial fermentation (Bacillus subtilis natto) without animal-derived inputs and is suitable for vegetarian and vegan capsules.
Q:Does it contain soy allergen?
A: Nattokinase is fermented on a soybean-based substrate; the finished purified enzyme is tested for residual soy protein, and a full allergen statement is provided with each batch.
Q: What is the MOQ and lead time?
A:MOQ is 25 kg for enzyme powders; lead time is 3 to 15 days after order confirmation, with custom activity and coating options.
Q:How is enzyme activity verified?
A:Every batch is assayed for FU activity using a validated fibrinolytic test method, and the COA reports activity, heavy metals, microbiology and purity.
Contact KH Health today to request a sample of nattokinase enzyme powder, discuss your formulation needs, or get a competitive quote.
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